High nuclearity nickel compounds with three, four or five metal atoms showing antibacterial activity》.pdf

Journal of Inorganic Biochemistry 93 (2003) 256–264 /locate/jinorgbio H igh nuclearity nickel compounds with three, four or five metal atoms showing antibacterial activity a b a b Maria Alexiou , Ioannis Tsivikas , Catherine Dendrinou-Samara , Anastasia A. Pantazaki , c d b , * a , * Pantelis Trikalitis , Nikolia Lalioti , Dimitris A. Kyriakidis , Dimitris P. Kessissoglou aLaboratory of Inorganic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece bLaboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece cDepartment of Chemistry, Michigan State University, East Lansing, MI 48824 -1322, USA dDepartment of Materials Science, University of Patras, Patras 26500, Greece Received 27 August 2002; accepted 4 October 2002 Abstract The effect on DNA and the antibacterial activity of a series of high nuclearity nickel compounds with three, four and five metal atoms were examined. The compounds have a mixed ligand composition with salicylhydroxamic acid and di-2-pyridyl-ketonoxime as chelate agents. In the trinu