High-Density Lipoprotein Cholesterol, High-Density Lipoprotein Particle Size, and Apolipoprotein A-I Significance for Cardiovascular Risk The IDEAL and EPIC-Norfolk Studies》.pdf

Journal of the American College of Cardiology Vol. 51, No. 6, 2008 © 2008 by the American College of Cardiology Foundation ISSN 0735-1097/08/$34.00 Published by Elsevier Inc. doi:10.1016/j.jacc.2007.09.060 High-Density Lipoprotein Cholesterol, High-Density Lipoprotein Particle Size, and Apolipoprotein A-I: Significance for Cardiovascular Risk The IDEAL and EPIC-Norfolk Studies Wim A. van der Steeg, MD,* Ingar Holme, PHD,† S. Matthijs Boekholdt, MD, PHD,* Mogens Lytken Larsen, MD, DMSC,‡ Christina Lindahl, MD,§ Erik S. G. Stroes, MD, PHD,* Matti J. Tikkanen, MD, PHD, Nicholas J. Wareham, MBBS, PHD,¶ Ole Faergeman, MD, DMSC,‡ Anders G. Olsson, MD, PHD,# Terje R. Pedersen, MD, PHD,† Kay-Tee Khaw, MBBCHIR,** John J. P. Kastelein, MD, P HD* Amsterdam, the Netherlands; Oslo, Norway; Århus, Denmark; Täby and Linköping, Sweden; Helsinki, Finland; and Cambridge, United Kingdom Objectives This study was designed to assess the relationship of high-density-lipoprotein cholesterol (HDL-C), HDL particle size, and apolipoprotein A-I (apoA-I) with the occurrence of coronary artery disease (CAD), with a focus on the effect of very high values of these parameters. Background High plasma levels of HDL-C and apoA-I are inversely related to the risk of CAD. However, recent data suggest that this relationship does not hold true for very high HDL-C levels, particularly when a preponderance of large HDL particles is observed. Metho