Interleukin-1β promotes the neurogenesis of carotid bodies by stimulating the activation of ERK12》.pdf

Respiratory Physiology Neurobiology 219 (2015) 78–84 Contents lists available at ScienceDirect Respiratory Physiology Neurobiology j o u rn al h o m e p a g e : w w w. elsev /locate/res physiol Interleukin-1 promotes the neurogenesis of carotid bodies by stimulating the activation of ERK1/2 Fen Xue a,b,1, Ling Liu c,1, Juan Fan d,1, ShanShan He a , Rui Li a , Zheng-Wu Peng a,b,∗ , Bai-Ren Wang c,∗∗ a Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China b Department of Toxicology, Shaanxi Key Lab of Free Radical Biology and Medicine, The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi’an 710032, China c Institute of Neuroscience, Fourth Military Medical University, Xi’an 710032, China d College of Life Science, Shaanxi Normal University, China a r t i c l e i n f o a b s t r a c t Article history: The carotid body (CB) is a complex sensory organ that functions to sense homeostatic O2 in the blood. Received 1 June 2015 Previous studies have shown that CBs express interleukin (IL)-1 receptor type I and that the chemosensi- Received in revised form 24 August 2015 tivity of CBs is increased following stimulation with pro-inflammatory cytokines. However, the effects of Accepted 25 August 2015 pro-inflammatory cytokines, such as IL-1, on the neurogenesis of CB are unclear. Thus, in this study, we aimed to assess the effects of IL-