Investigation of C-terminal domain of SARS nucleocapsid protein–Duplex DNA interaction using transistors and binding-site models》.pdf

Sensors and Actuators B 193 (2014) 334–339 Contents lists available at ScienceDirect Sensors and Actuators B: Chemical j o u rn al h o m e p ag e: w w w. elsev / l o c a t e/ s n b General Investigation of C-terminal domain of SARS nucleocapsid protein–Duplex DNA interaction using transistors and binding-site models You-Ren Hsu a , Yen-Wen Kang a , Jung-Ying Fang a , Geng-Yen Lee b , Jen-Inn Chyi b , Chung-ke Chang c , Chih-Cheng Huang a , Chen-Pin Hsu a , Tai-huang Huang c , Yu-Fen Huang d , Yuh-Chang Sun d , Chia-Hsien Hsu e , Chih-Chen Chen e , Sheng-Shian Li a , a a f a,∗ J. Andrew Yeh , Da-Jeng Yao , Fan Ren , Yu-Lin Wang a Institute of Nanoengineering and Microsystems, National Tsing Hua University, Hsinchu, 300, Taiwan, ROC b Department of Electrical engineering, National Central University,Jhongli, Taoyuan 32001, Taiwan, ROC c Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei 11529, Taiwan, ROC d Department of Biomedical Engineering and Environmental Science, National Tsing Hua University, Hsinchu 300, Taiwan, ROC e Division of Medical Engineering, National Health Research Institutes, MiaoLi, Taiwan, ROC f Department of Chemical Engineering, University of Florida, Gainesville, FL 32611, USA a r t i c l e i n f o a b s t r a c t Article history: AlGaN/GaN high electron mobility transistors (HEMTs) were used to sense the binding between double Received 20 November 2012 stranded DNA (dsDNA) and the severe acute respiratory syndrome coronavirus (SARS-CoV) nucleocap- Received in revised form