Maintenance of GABAergic Activity by Neuregulin 1-ErbB4 in Amygdala for Fear Memory》.pdf

Neuron Article Maintenance of GABAergic Activity by Neuregulin 1-ErbB4 in Amygdala for Fear Memory Yisheng Lu,1,8 Xiang-Dong Sun,1,2,8 Feng-Qing Hou,2 Lin-Lin Bi,2 Dong-Min Yin,1,6 Fang Liu,1 Yong-Jun Chen,1,7 Jonathan C. Bean,1 Hui-Feng Jiao,1,5 Xihui Liu,1,9 Bao-Ming Li,5 Wen-Cheng Xiong,1,3,4 Tian-Ming Gao,2,* and Lin Mei1,3,4,5,* 1Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA 2State Key Laboratory of Organ Failure Research, Key Laboratory of Psychiatric Disorders of Guangdong Province, Department of Neurobiology, Southern Medical University, Guangzhou 510515, China 3Department of Neurology, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA 4Charlie Norwood VA Medical Center, Augusta, GA 30912, USA 5Center for Neuropsychiatric Diseases, Institute of Life Science, Nanchang University, Nanchang 330031, China 6Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai 200062, China 7Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510407, China 8Co-first author 9Present address: Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA *Correspondence: tgao@ (T.-M.G.), lmei@ (L.M.) /10.1016/j.neuron.2014.09.029 SUMMARY Whalen, 2001; LeDoux, 2000; McGaugh, 2004; Sah et al., 2003). The amygdala is a group of nuclei in the medial temporal Inhibitory neurotransmission in amygdala is impor- lobes of the brain. Its basolateral nuclei (i.e., basolateral amyg- tant for fear learning and memory. However, mecha-