Mussel-inspired adhesive and transferable free-standing films by self-assembling dexamethasone encapsulated BSA nanoparticles and vancomycin immobilized oxidized alginate》.pdf

Colloids and Surfaces B: Biointerfaces 126 (2015) 452–458 Contents lists available at ScienceDirect Colloids and Surfaces B: Biointerfaces j o u r n a l h o me p a g e : w w w. elsev /locate/cols urfb Mussel-inspired adhesive and transferable free-standing films by self-assembling dexamethasone encapsulated BSA nanoparticles and vancomycin immobilized oxidized alginate Lu Han a , Zhen-ming Wang a , Xiong Lu a,∗ , Li Dong a , Chao-ming Xie a , Ke-feng Wang b , Xiao-lang Chen a , Yong-hui Ding c , Lu-tao Weng c a Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, China b National Engineering Research Centerfor Biomaterials, Sichuan University, Chengdu, Sichuan, China c Department of Mechanical and Aerospace Engineering and Materials Characterisation and Preparation Facility, Hong Kong University of Science and Technology, Hong Kong, China a r t i c l e i n f o a b s t r a c t Article history: This study developed an adhesive and transferable free-standing (FS) film with dual function of Received 22 August 2014 osteoinductivity and antibacterial activity, which was obtained by sequentially assembling vancomycin Received in revised form immobilized oxidized sodium alginate and dexamethasone encapsulated chitosan coated BSA nanoparti- 25 December 2014 cles on a poly-dopamine layer. The FS films enabled the dual release of vancomycin and dexamethasone. Accepted 29 December 2014