Osteogenesis and angiogenesis properties of dental pulp cell on novel injectable tricalcium phosphate cement by silica doped》.pdf

Materials Science and Engineering C 42 (2014) 672–680 Contents lists available at ScienceDirect Materials Science and Engineering C j ournal homepage: www.el sevier.c om/l ocate/ ms ec Osteogenesis and angiogenesis properties of dental pulp cell on novel injectable tricalcium phosphate cement by silica doped Ying-Fang Su a,b,c,1, Chi-Chang Lin d,1, Tsui-Hsien Huang b,c, Ming-Yung Chou b,c, Jaw-Ji Yang e,⁎,2, Ming-You Shie d,⁎⁎,2 a Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan b Department of Stomatology, Chung Shan Medical University Hospital, Taichung, Taiwan c School of Dentistry, Chung Shan Medical University, Taichung, Taiwan d Department of Anatomy, Chung Shan Medical University, Taichung City, Taiwan e Department of Chemical and Materials Engineering, Tunghai University, Taichung, Taiwan a r t i c l e i n f o a b s t r a c t Article history: β-Tricalcium phosphate (β-TCP) is an osteoconductive material in clinical. In this study, we have doped silica (Si) Received 5 February 2014 into β-TCP and enhanced its bioactive and osteostimulative properties. To check its effectiveness, a series of Si- Received in revised form 3 April 2014 doped with different ratios were prepared to make new bioactive and biodegradable biocomposites for bone re- Accepted 7 May 2014 pair. Formation of the diametral tensile strength, ions released and weight loss of cements was considered after Available online 23 May 2014 immersion. In addition, we also