Plasma apolipoprotein A-I levels and bile lipid secretion during thoracic duct drainage in the rat》.pdf

Biochimica et Biophysics Acta, 963 (1988) 231-236 231 Elsevier BBA 52986 Plasma apolipoprotein A-I levels and bile lipid secretion during thoracic duct drainage in the rat Ake Nilsson a, Britta Landin b and Bengt Johansson ’ 0Department of Internal Medrcine, h Research Department 2, Unroersity Hosprtal of Lund, Lund (Sweden) and ’ Dakopatts a/s, Copenhagen (Denmark) (Received 30 August 1988) Key words: Apolipoprotein A-I; Bile: Bile diversion; Lymph diversion; (Rat) A large part of the circulating apolipoprotein A-I (apoA-I) is produced by the intestine. Yet the plasma levels of apoA-I are retained or even increased in rats with thoracic duct drainage (Johansson, B. and Nilsson, A, (1981) FEBS Lett. 130, 305-308 and Franzen, J. et al. (1987) Bhim. Biophys. Acta 918, 11-15). In this study we examined the effects of biliary drainage and of combined biliary and lymphatic drainage on the plasma apoA-I levels, and also the effects of lymphatic drainage on the output of biliary lipids in the rat. 63 h of biliary drainage caused a 40% decrease of the serum apoA-I concentration. In contrast the concentration in rats with combined thoracic duct and biliary drainage was 153% of that in contro