Plasma concentrations of apolipoproteins A-I, B, and M in patients with critical limb ischemia》.pdf

Clinical Biochemistry 43 (2010) 599–603 Contents lists available at ScienceDirect Clinical Biochemistry journal homepage: www.else vi /l oca te/clinbiochem Plasma concentrations of apolipoproteins A-I, B, and M in patients with critical limb ischemia Jose fin Ahnström a, Anders Gottsäter b, Bengt Lindblad b, Björn Dahlbäck a,⁎ a Lund University, Department of Laboratory Medicine, Division of Clinical Chemistry, Wallenberg laboratory, entrance 46, fl oor 6, University Hospital, Malmö, S-20502 Malmö, Sweden b Vascular Centre Malmö-Lund, University Hospital, SE-205 02 Malmö, Sweden a r t i c l e i n f o a b s t r a c t Article history: Objectives: Apolipoproteins affect development of atherosclerosis, but their involvement in the pathoge- Received 1 December 2009 nesis of critical limb ischemia (CLI), a severe form of atherosclerosis, has not previously been examined. Received in revised form 5 January 2010 Design and methods: ApoA-I, apoB, and apoM were measured in plasma from 196 CLI subjects and 214 Accepted 7 January 2010 control individuals from the background population. Available online 18 January 2010 Results: Cases had lower levels of the apolipoproteins, as compared to controls; apoA-I, 1.23 vs. 2.08 g/L; apoB, 0.93 vs. 1.04 g/L; apoM, 0.75 vs. 0.91 μmol/L (p b 0.0001 for all three). ApoA-I and apoM correlated negatively with Keywords: inflammatory markers and positively to 1- and 3-year survival rates, whereas apoB did not