Preventive effects of cranberry products on experimental colitis induced by dextran sulphate sodium in mice》.pdfVIP

Food Chemistry 167 (2015) 438–446 Contents lists available at ScienceDirect Food Chemistry journal homepage: www.elsevi /locat e/foodchem Preventive effects of cranberry products on experimental colitis induced by dextran sulphate sodium in mice Xiao Xiao a, Jonggun Kim a, Quancai Sun a, Daeyoung Kim b, Cheon-Seok Park c, Tzong-Shi Lu d, Yeonhwa Park a,c,⇑ a Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA b Department of Mathematics and Statistics, University of Massachusetts, Amherst, MA 01003, USA c Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University, Yongin 446-701, Republic of Korea d Harvard Medical School, Brigham and Women’s Hospital, HIM 550, 77 Avenue Louis Pasteur, Boston, MA 02115, USA a r t i c l e i n f o a b s t r a c t Article history: With the prevalence of inflammatory bowel disease (IBD) and its associated risk for development of colo- Received 24 February 2014 rectal cancer, it is of great importance to prevent and treat IBD. However, due to the complexity of eti- Received in revised form 17 May 2014 ology and potentially serious adverse effects, treatment options for IBD are relatively limited. Thus, the Accepted 1 July 2014 purpose of this study was to identify a safe food-based approach for the prevention and treatment of Available online 9 July 2014 IBD. In this study, we tested the effects of cranberry products on preventing dextran sulphate sodium-