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血脂康+辛伐他汀.doc
联合辛伐他汀和血脂康治疗急性冠脉综合征疗效及安全性研究
王淑红1, 赵国安2,金培印1,韩勤甫1,申娟1,贾银明1
摘要:目的 探讨联合应用辛伐他汀和血脂康对急性冠脉综合征(ACS)患者血脂、血管内皮功能及炎症因子的影响,并评估其安全性。
方法 72例ACS患者,随机分3组:辛伐他汀组(0mg·d -1, n=22)(1.2gd -1,n=24)(mg·d -1+血脂康1.2g·d -1, n=26)(TC)、(LDL)、(TG)(HDL) (ET)(NO)C反应蛋白(CRP) 联合辛伐他汀和血脂康治疗可以更全面地改善ACS患者的血脂异常,改善内皮功能和降低炎症因子的作用较单药治疗更有效。联合辛伐他汀和血脂康治疗具有良好的安全性和耐受性。
关键词 辛伐他汀;血脂康;急性冠脉综合征;治疗
Efficacy and safety of combination therapy with simvastatin and Xuezhikang for acute coronary syndrome
Wang shuhong, Jin peiyin,Hanqinfu,et al
(Department of Cardiology, Anyang People,s Hospital,455000)
Abstract: Objectives The aim of this study was to investigate the influences of combination therapy with Xuezhikang(XZK) and simvastatin on serum-lipids and vascular endothelial function, as well as evaluate the safety of this therapy in patients of acute coronary syndrome(ACS). Methods 72 patients of ACS were randomly divided into three groups: First, simvastatin alone group(20mg?d -1 n=22); The second, XZK group (1200mg?d -1 ,n=24); The third, combined group(20mg simvastatin +1200mg XZK·d -1 n=26). All the groups were oberserved for 2 months. At the time of before and after treatments 30 and 60 day, Total cholesterol (TC), Low-density lipoprotein (LDL)-cholesterol, Triglycerides (TG), high-density lipoprotein (HDL)-cholesterol as well as nitricoxide(NO), endothelin(ET), C-reactive protein (CRP) were measured. In addition, adverse effects were observed. Results Compared with the treatment before, TC, LDL and TG were significantly decreased (P0.05), and HDL were increased to some extent in every group. Of all the group, the combined group was the most effective. Compared with simvastatin alone group or XZK alone group, the TC, LDL and TG of combined group were significantly lower and HDL were significantly higher(P0.05). There were no differences of TC and LDL between simvastatin group and XZK group, but TG were significantly decreased (P0.05) and HDL were significantly increased in XZK group compa
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