神经肽SP对NK92-MI细胞生物学功能影响及研究.pdf

／嬲嬲炒 目 录 一， 摘要 中文论著摘要·····································I 英文论著摘要·····································6 二， 英文缩略语······································Ii 三， 论文一 前言············································12日曼J舌 ············································ lZ 材料和方法······································13 实验结果········································22 讨{《≥············································26 结论············································30 四， 论文二 前言············································31日lJ舌·······························。············3l 材料和方法······································32 实验结果········································36 讨t《≥············································39 结论············································43 五， 论文三 前言············································44日曼J看 ············································44 材料和方法······································45 实验结果········································52 讨论············································56 结论············································59 六、 本研究创新性的自我评价··························60 七、参考文献········································61 八、 附录 (1)综述············································70 (2)在学期间科研成绩································96 (3)致谢············································97 (4)个人简介········································98 ·中文论著摘要· 神经肽SP对NK92．MI细胞生物学功能影响的研究 刖吾 神经内分泌系统对机体免疫功能具有重要的调控作用。经典神经递质、神经 肽是直接作用于免疫活性细胞和其他参与免疫反应细胞的重要调节物质。P物质 (Substance PSP)是发现最早的神经肽之一，属于哺乳动物速激肽家族。中枢神 经系统的神经元和神经胶质细胞是SP的主要来源，免疫细胞是sP的另一来源。 外周神经末梢释放SP参与免疫调节和炎症过程，免疫细胞产生SP以自分泌或／ 和旁分泌的方式调节免疫细胞的功能。SP可从多方面影响各种免疫细胞，且SP 在不同条件下所起的作用具有复杂性和多样性。SP可以影响淋巴细胞的增殖、分 化，诱导免疫球蛋白和细胞因子的合成，并能够调节Th细胞的活性和其他