灵芝酸T聚合物纳米胶束的构建及抗肿瘤机制的分析.pdf

郑 重 声 明 本人郑重声明：所呈交的博士后研究工作报告，是本人在博士后导师的指导 下，独立进行研究工作所取得的成果。除文中已经注明引用的内容外，本论文不 包含任何其他个人或集体已经发表或撰写过的作品成果。对本文的研究做出重要 贡献的个人和集体，均已在文中以明确方式标明。本人完全意识到本声明的法律 结果由本人承担。 作者(签名)：苏越 2012年11月16同 II T III well-knownwhichwithwerewaswithwereMichealAbstractAcidAnti．．CancermoremoremedicinalmolecularmechanismsmainmechanismNano．．MicellesMechanismsbioactivebecausePostdoctorYuehaveherb．GanodericGanodermaGA-TGA-T．TheGA-TGA—TaareashumanChemicalChineseremarkablekindsnano-micellesnano-micelles．Innano—micellesresultsTTheirnano-micellesGanodericZhucancerSchoolandandattractedandattentionacidanti—cancerand95-Dalsoandandanti-cancer95一DadditionConstructionLoadedofofofofofSutofieldfromandanti-cancercarriersconstructedcellscellsconclusionscellsofandtheirthetraditionalthisexcellentevaluatedthesetheirofIVlucidumlucidum．haslimitedloadedloadedloadedinisisisitsinhibitionin1．Constructionshown werewerewaswaswerewithwaswerewerewaswerewaswerewithwaswhenwerewithwithwerewaswaswerewithwerewerewithNIH一3T3NIH一3T3NIH-3T3NMRMTTNMRMTTVmin．molecularmn．ThemechanismmolecularHPEGHPEGHPEGHPEGHPEGHPEGDLSnnl．FTIRunderbehaviorunderunderPEG-b-PCLFTIR．ItsPEG—b—PCLunderPEG-b-PCLPEG-b-PCLThehhGA—ThGA—ThasaTEM．Thehumanresultsnano-micellesresultsresultsresultsnano—micellesnano．micellesatnano—micellesnano—micellesnano．micellesnano—micellesnano·-micellesnano-micellesnano—micellesnano-micellesandand95-D95一Dandand95一D95-D95-D95一Dandanti．cancerandand95excessofofofofofofofofofofofofofofof85％when24220024242．Construction2465％whenenterforflowforforforandandandcharacterizedcells．Thecellcellsconcentrationcellulardetection．Thedemonstratedcouldcells5characterizatedcellcellsconcentration50couldcellsconcentration50cells．cervicalcharacterizedcells．Thecellcellsconcentrationcharacterizatedforterminalstreatedthatthenthattreatedthatthetreatedthatthetheirtreatedtheconfocaldiamete