论文腺苷的药理活性及其研究进展.ppt

本科生毕业论文（设计） 腺苷的药理活性及其研究进展 Adenosine pharmacological activities and its research progress Abstract: Adenosine by adenine N - 1-9 and D - ribose C through beta can be connected with the glycosidic bond compound, its for adenosine phosphate. Adenosine is a kind of endogenous nucleoside throughout the human body cell, can directly into the myocardium via phosphorylation generating adenosine, participate in myocardial energy metabolism, also participate in the expansion of coronary artery blood vessels, increase blood flow.Adenosine on the cardiovascular system, and many other systems of the body and the organization have physiological function. Adenosine on the cardiovascular system, and many other systems of the body and the organization have a physiological role. Adenosine is used in the synthesis of adenosine triphosphate (ATP), adenine, adenosine, vidarabine important intermediates. Adenosine pharmacological activities can be reduce the sinoatrial node and the atrioventricular node and the self-discipline of atrial muscles and extension of the atrioventricular node refractory period, slow conduction.Its mechanism of action is the activation of adenosine receptors, activate potassium channels, promote potassium outflows, make the cell membrane hyperpolarization, and it also inhibits the inflow cAMP, the activation of calcium ions, is a common arrhythmia drug resistance. The current study of adenosine is more and more comprehensive, now find currently found A1 adenosine receptors, both A2a, A2b and A3. Keywords: adenosine, Adenosine pharmacological activities, Mechanism of action, Adenosine receptors, 目 录 摘要…………………………………………………………………………3 前言…………………………………………………………………………4 第一章 文献综述…………………………………………………………5 1.1 腺苷形态………………………………………………………………5 1.2 腺苷的化学式…………………………………………………………5 1.3 腺苷的形成…………………………………………………………5 1.4 腺苷的药理活性………………………………………………………5 第二章 腺苷的研究进展…………………………………………………7 参考文献……………………………………………………………………7 致谢…………………………………………………………………………14 前言 早在1929年，Drury[1]和Szent-Gy