以取代氨基硫脲为手臂的新型脱氧胆酸类分子钳的微波合成有机化学.pdfVIP

DOI: 10.6023/cjoc201208031 研究论文 有机化学 Chinese Journal of Organic Chemistry ARTICLE 以取代氨基硫脲为手臂的新型脱氧胆酸类分子钳的微波合成 夏振洋 赵志刚* 石治川 刘 敏 (西南民族大学化学与环境保护工程学院 成都 610041) 摘要 在微波辐射条件下, 以脱氧胆酸甲酯为隔离基, 通过三光气桥连取代氨基硫脲为手臂, 以良好的产率合成了 10 个新型脱氧胆酸分子钳, 其结构均经 1H NMR, IR, MS 及元素分析确证. 微波法具有反应时间短, 产率高, 对环境友好 等优点. 利用差紫外可见光光度滴定法测试了主体化合物对 Cl－, Br－, I－, NO－ 等阴离子的识别作用. 实验结果表明, 3 主体对阴离子有良好的识别性能. 关键词 脱氧胆酸; 分子钳; 微波合成; 分子识别 Microwave-Assisted Synthesis of Novel Molecular Tweezers Based on Deoxycholic Acid with Arm of Substituted Thiosemi- carbazides Xia, Zhenyang Zhao, Zhigang* Shi, Zhichuan Liu, Min (College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041) Abstract Ten new molecular tweezers based on deoxycholic acid were synthesized in good yields by using deoxycholic acid methyl ester as spacer to bridge different substituted thiosemicarbazides via triphosgene under microwave irradiation. Their structures were charactetized by 1H NMR, IR, MS techniques and elemental analysis. The microwave method has distinct advantages such as short reaction time, high yields and eco-friendly to the environment. The recognition properties of these molecular tweezers for Cl－, Br－, I－, NO－ anions were investigated by UV-vis spectra titration. The result indicated that this 3 type of molecular tweezers has good