低共熔溶剂中新型螺环吲哚衍生物的绿色合成有机化学.pdfVIP

DOI: 10.6023/cjoc201409028 研究论文 有机化学 Chinese Journal of Organic Chemistry ARTICLE 低共熔溶剂中新型螺环吲哚衍生物的绿色合成 严 楠*,a,b 熊云奎b 夏剑辉b 芮培欣b 雷志伟a 廖维林*,a 熊 斌a,b (a 国家单糖化学合成工程技术研究中心 南昌 330027) (b 江西师范大学化工研发中心 南昌 330027) 摘要 在低共熔溶剂氯化胆碱/ 草酸催化作用下, 由醛、吲哚和 6,10- 二氧杂螺[4.5]十烷-7,9- 二酮三组分多米诺 Knoevenagel-Michael 反应合成了一系列新型螺环吲哚衍生物, 产率为 70%～97%. 该方法条件温和, 操作简单, 反应时 间短, 对环境友好等优点, 且催化剂廉价易得. 关键词 低共熔溶剂; 多米诺反应; 螺环吲哚衍生物; 绿色合成 Green Synthesis of Novel Spirooxindole Derivatives in Deep Eutectic Solvent *,a,b b b b Yan, Nan Xiong, Yunkui Xia, Jianhui Rui, Peixin Lei, Zhiweia Liao, Weilin*,a Xiong, Bina,b a ( National Monosaccharide Chemical Synthesis Engineering Research Center, Nanchang 330027) (b Chemical Research and Development Center, Jiangxi Normal University , Nanchang 330027) Abstract A series of novel spirooxindole derivatives were synthesized by three-component domino Knoevenagel-Michael reaction between aldehydes, indole and 6,10-dioxaspiro[4.5]decane-7,9-dione using the deep eutectic solvent (DES) choline chloride-oxalic acid as a catalyst in 70%～97% yields. This method has some distinct advantages such as easy work-up, mild reaction conditions, short reaction time, environmental friendliness and accessibility of catalyst. Keywords deep eutectic