偶氮二甲酸酯在有机合成中的研究进展有机化学.pdf

DOI: 10.6023/cjoc1110313 综述与进展 有机化学 Chinese Journal of Organic Chemistry REVIEW 偶氮二甲酸酯在有机合成中的研究进展 许孝良* 程国华 李小年* (浙江工业大学化学工程与材料学院 杭州 310032) 摘要 偶氮二甲酸酯由于具有独特的电子和结构特性, 作为一种多功能化的试剂在有机合成中得到了广泛的应用. 特 别是在 Mitsunobu 反应、羰基化合物的氨化、不饱烃的氨化及杂环化合物的合成中有着非常重要的作用, 此外偶氮二 甲酸酯还可以作为氧化剂, 用于醇、胺的脱氢氧化反应. 回顾了其在有机合成中原有的应用基础之上, 对其近年来在合 成化学中的新发展进行了综述, 并对其发展加以展望. 关键词 偶氮二甲酸酯; 有机合成; 碳氮键形成 Application of Azodicarboxylates in Organic Synthesis Xu, Xiaoliang* Cheng, Guohua Li, Xiaonian* (College of Chemical Engineering and Material Science, Zhejiang University of Technology, Hangzhou 310032) Abstract Azodicarboxylates, as versatile reagents, have been widely used in organic synthesis due to their unique electronic and structural properties. They have played important roles in organic synthesis such as Mitsunobu reaction, amination of car- bonyl compounds and unsaturated hydrocarbons, synthesis of heterocyclic compounds. Besides these, azodicarboxylates can be used as oxidants for the dehydrogenation of alcohols and amines. Based on their previous applications, new progress of azodicarboxylates in synthetic chemistry in recent years is summarized and an outlook on their development is also given. Keywords azodicarboxylates; organic synthesis; C—N bond formation 偶氮二甲酸酯是一类同时带有偶氮和羧基官能团 MeO2C N EtO2C N 的化合物, 比较常见的有偶氮二甲酸二甲酯(DMAD)、 N CO2Me N CO2Et 偶氮二甲酸二乙酯(DEAD) 、偶氮二甲酸二异丙酯 DMAD D