催化不对称反应新发展不对称活化有机化学.pdfVIP

有机化学 Vo 1. 20 , 2仪lO 2削;1 第 20 l主 第 l 则， 1 - 10 Chines( Jυilll1 lal of or萨nic ChemÎstly No.l , 1-10 ·综述与进展· y 催化不对称反应新进展一不对称活化 帮 y / 丁奎岭〉 林国强 (中国科学院仁海有权L ~七学研究所 上海 2仪l(32) 摘要 介绍了催化不对称催化反应中的 p 个新概念一不对前:活化(出严unctric activation) 及其研究的必威体育精装版进展υ 运用不对 称活化策略，→个光学活性的或者甚至外消旋的催化剂可以被另→种子性活化剂(d世ral activator) 选择性地活化，从而催化反 应生成非外泊旋产物。该方法较不对称去?活后化(a描sy川nillJctn时c 也『d f催萨化剂更高对映体过f量注的产物ζο} 关键词 不对称活化，催化，于性 Recent Advances in Catalytic Asymmetric Reactions - Asymmetric Activation DlNG Kui - Ling 提. LI N Guo - Qiang ( Shar时皿 ImtÍllLle 0/ Orgw旧 Chell山町、 Chinese AcadernJ 0/ Sciew.es , 2脚~2 Shanghai) Abstract A new slrategy fm 凶ynunetric s)l1thesis , namely aS)l1UDctric activation , is presenLcd and some of its re- ccnt advances are rcviewed. WiÙl as严nmctric activation sLrategy , a chiral or cven racemic catalyst may be sclectively ac- tivatcd by a chiral activator to yield non - racemic productô. The advantage of this approach over the deactivation strategy is that the activated catalyst can produce a greater cnantiomeric excess in the products than the cnantiomerically pure cat- ah 51 can a