分子印迹技术用于模拟酶及分子反应器的研究进展有机化学.pdfVIP

2009 年第 29 卷 有 机 化 学 Vol. 29, 2009 第 11 期, 1744～1749 Chinese Journal of Organic Chemistry No. 11, 1744～1749 ·综述与进展· 分子印迹技术用于模拟酶及分子反应器的研究进展 娄忠良 孟子晖* 王 鹏 孟文君 (北京理工大学化工环境学院 北京 100081) 摘要 分子印迹技术是制备特异性分子识别材料的新技术. 分子印迹聚合物(Molecularly-imprinted polymer, MIP)具有 可同酶相媲美的选择性识别能力, 能够催化手性及区域选择性的反应, 是一种新型的分子反应器; 同时 MIP 具有良好 的化学和物理稳定性, 因而在替代酶用于某些苛刻条件下的催化反应方面有良好的应用前景. 就近年来利用 MIP 模拟 酶催化有机合成反应, 以及利用 MIP 作为分子反应器反面的研究进展进行了综述. 关键词 分子印迹; 模拟酶催化; 高分子催化剂; 分子反应器 Application of Molecular Imprinting Technology to Enzyme Mimics and Molecular Reaction Vessels Lou, Zhongliang Meng, Zihui* Wang, Peng Meng, Wenjun (School of Chemical Engineering and the Environment, Beijing Institute of Technology, Beijing 100081) Abstract Molecular imprinting is a promising technology in the preparation of highly selective materials. Molecularly-imprinted polymers (MIP) are comparable to enzymes in the selectivity towards target mole- cules, and can be used to catalyze chiral-selective, stereo-selective and regio-selective reactions, which are now regarded as a novel molecular reaction vessel. They show outstanding chemical and physical stability, thus can be used under harsh chemical environments instead of enzymes. In this review, utilization of MIP as enzyme mimics to catalyze synthetic reactions, and as molecular reaction vessel is summarized. Keywords molecularly imprinting; enzyme mimics; polymeric catalyst; molecular reaction vessel 催化过程是大多数有机合成反应所不可缺少的过 材料易得、价廉、便于贮存等要求. 分子印迹技术的出 程. 在众多催化过程中, 酶催化以其高效、专一、反应 现及其在模拟抗体方面取得的突破