咔唑及其衍生物合成方法研究进展有机化学.pdfVIP

DOI: 10.6023/cjoc1109031 综述与进展 有机化学 Chinese Journal of Organic Chemistry REVIEW 咔唑及其衍生物合成方法研究进展 房旭彬a,b 房 雷*,a,b 苟少华*,a,b (a 东南大学药物研究中心 南京 211189) (b 江苏省生物药物高技术研究重点实验室 南京 211189) 摘要 咔唑及其衍生物是一类重要的含氮芳杂环化合物, 具有许多独特的理化性质及生物活性, 分析、归纳、总结了 近 5 年来发表的文献, 选取具有代表性的实例, 并按照中间体的不同将合成方法分为四类, 分别讨论了咔唑及其衍生 物合成方法的进展情况, 对咔唑及其衍生物成环的新方法给予重点关注. 关键词 咔唑; 衍生物; 合成方法; 研究进展 Progresses in Synthetic Methods of Carbazole and Its Derivatives Fang, Xubina,b Fang, Lei*,a,b Gou, Shaohua*,a,b a ( Pharmaceutical Research Center, Southeast University, Nanjing 211189) b ( Jiangsu Province Hi-Tech Laboratory for Bio-medical Research, Southeast University, Nanjing 211189) Abstract Carbazole and its derivatives are a class of important nitrogen-containing heterocyclic compounds possessing various unique properties and biological activity. Herein the current progress of their synthetic strategies reported in the past 5 years is reviewed. The representative examples, which have been divided into four categories according to the usage of differ- ent key intermediates, are selected and discussed in detail. Special emphasis is put on the newly developed cyclization reac- tions which may be useful for the construction of the tricyclic backbone of carbazoles. Keywords carbazole; derivatives; synthetic methods; progress 咔唑是一种含氮的杂环化合物, 是许多精细化学品 应、Bucherer 咔唑合成和 Borsche-Drechsel 环化反应. 的中间体