《SVHC-42 醋酸钴 Cobalt_II_diacetate(CR 致癌与生殖毒性)》.pdf

SVHC SUPORT DOCUMENT Substance name: Cobalt(II) diacetate EC number: 200-755-8 CAS number: 71-48-7 MEMBER STATE COMMITTEE SUPPORT DOCUMENT FOR IDENTIFICATION OF COBALT(II) DIACETATE AS A SUBSTANCE OF VERY HIGH CONCERN BECAUSE OF ITS CMR PROPERTIES Adopted on 2 December 2010 1 SVHC SUPPORT DOCUMENT CONTENTS 1 IDENTITY OF THE SUBSTANCE AND PHYSICAL AND CHEMICAL PROPERTIES 5 1.1 Name and other identifiers of the substance 5 1.2 Composition of the substance6 1.3 Physico-chemical properties6 2 HARMONISED CLASSIFICATION AND LABELLING 7 2.1 Classification according to Directive 67/548/EEC 7 2.2 Classification according to Regulation EC 1272/2002 7 3 ENVIRONMENTAL FATE PROPERTIES9 4 HUMAN HEALTH HAZARD ASSESSMENT9 5 ENVIRONMENTAL HAZARD ASSESSMENT 9 6 CONCLUSIONS ON THE SVHC PROPERTIES 10 6.1 PBT, vPvB assessment 10 6.2 CMR assessment10 1 ANNEX I: HUMAN HEALTH HAZARD ASSESSMENT 14 1.1 Toxicokinetics (absorption, metabolism, distribution and elimination) 14 1.1.1 Human information 14 1.2 Acute toxicity 15 1.3 Irritation15 1.4 Corrosivity15 1.5 Sensitisation16 1.6 Repeated dose toxicity16 1.7 Mutagenicity16 1.7.1 Non-human information 16 1.7.2 Human data 17 1.7.3 Other relevant information 17 1.7.4 Summary and discussion of mutagenicity20 1.8 Carcinogenici