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Ethnic Differences in C-Reactive Protein strongConcentrationsstrong.pdf
Clinical Chemistry 54:6 Lipids, Lipoproteins, and Cardiovascular Risk Factors
1027–1037 (2008)
Ethnic Differences in C-Reactive Protein
Concentrations
Alyson Kelley-Hedgepeth,1 Donald M. Lloyd-Jones,2 Alicia Colvin,3 Karen A. Matthews,4 Janet Johnston,5
MaryFran R. Sowers,6 Barbara Sternfeld,7 Richard C. Pasternak,8 and Claudia U. Chae,9*
for the SWAN Investigators
BACKGROUND: Limited data exist regarding the ethnic of these ethnic differences and their implications for
differences in C-reactive protein (CRP) concentra- the use of CRP in CVD risk prediction.
tions, an inflammatory marker associated with risk of © 2008 American Association for Clinical Chemistry
cardiovascular disease (CVD). We hypothesized that
known CVD risk factors, including anthropometric
characteristics, would explain much of the observed Cardiovascular disease (CVD)10 has a significant im-
ethnic variation in CRP.
pact on morbidity and mortality worldwide and is the
leading cause of death in the United States in women,
METHODS: We performed a cross-sectional analysis of as in men (1). C-reactive protein (CRP), a marker of
3154 women, without known CVD and not receiving systemic inflammation, is independently associated
hormone therapy, enrolled in the Study of Women’s with risk of myocardial infarction and cardiovascular
Health Across the Nation (SWAN), a multiethnic death in prospective cohort studies (2–4). The Amer-
prospective study of
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