Foxp3+ regulatory strongTstrong cells differentiation, specification,.pdfVIP

r e v i e w + Foxp3 regulatory T cells: differentiation, specification, subphenotypes Markus Feuerer1,2, Jonathan A Hill1,2, Diane Mathis1,2 Christophe Benoist1,2 Regulatory T cells (Treg cells) characterized by expression of the transcription factor Foxp3 play a key role in immune homeostasis. . Rather than a monomorphic population strictly determined by Foxp3 as a ‘master regulator’, the emerging view is one of Treg cells d e as a population with many levels of complexity. Several regulatory factors partake in the control of their transcriptional ‘signature’, v r with Foxp3 being a key regulator but insufficient and unnecessary to specify all aspects of the lineage. Distinct subphenotypes of e s e Foxp3+ Treg cells are found in different anatomical locations. Some subphenotypes specifically control different facets of effector r s T cell function and, perhaps surprisingly, share transcriptional control elements with the very cells they regulate. This review will t h focus on these novel aspects of T cell diversity. g reg i r l l A . Any biological system involves negative feedback, and it is now recog- been constructed, and these have been the subject of intense genomic, c nized that regulatory T cells (T cells) play key roles in the maintenance genetic and epigenetic investigation. More genome-wide transcriptional n reg I , of lymphoid homeostasis in a number of immune circumstances. These profiles have been generated on T cells than on any other immune cell a reg c