Free Radical Biology Medicine - Red HERACLES.pdfVIP

FRB-10805; No. of pages: 10; 4C: Free Radical Biology Medicine xxx (2011) xxx–xxx Contents lists available at SciVerse ScienceDirect Free Radical Biology Medicine journal homepage: /locate/freeradbiomed Original Contribution Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension Manuel Gómez-Guzmán a, Rosario Jiménez a, Manuel Sánchez a, María José Zarzuelo a, Pilar Galindo a, Ana María Quintela a, Rocío López-Sepúlveda a, Miguel Romero a, Juan Tamargo b, Félix Vargas c, Francisco Pérez-Vizcaíno b, d, Juan Duarte a,⁎ a Department of Pharmacology, School of Pharmacy, School of Medicine, University of Granada, 18071 Granada, Spain b Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Department of Pharmacology, School of Medicine, University Complutense of Madrid, 28040 Madrid, Spain c Department of Physiology, School of Medicine, University of Granada, 18071 Granada, Spain d Ciber Enfermedades Respiratorias, Madrid, Spain a r t i c l e i n f o a b s t r a c t Article history: Flavanol-rich diets have been reported to exert beneficial effects in preventing cardiovascular diseases, such Received 17 February 2011 as hypertension. We studied the effects of chronic treatment with epicatechin on blood pressure, endothelial Revised 13 September 2011 function, and oxidative status in deoxycorticosterone acetate (DOCA)-salt-ind