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Human Neural Stem Cell Replacement Therapy for
Amyotrophic Lateral Sclerosis by Spinal Transplantation
1 2,3 1 4 1
Michael P. Hefferan , Jan Galik , Osamu Kakinohana , Gabriela Sekerkova , Camila Santucci ,
1 1 1,8,9 5 6
Silvia Marsala , Roman Navarro , Marian Hruska-Plochan , Karl Johe , Eva Feldman ,
Don W. Cleveland7, Martin Marsala1,2*
1 Neuroregeneration Laboratory, Department of Anesthesiology, University of California San Diego, La Jolla, California, United States of America, 2 Institute of
ˇ ˇ
Neurobiology, Slovak Academy of Sciences, Kosice, Slovakia, 3 Institute of Biology and Ecology, Faculty of Science, Pavol Jozef Safarik University, Kosice, Slovakia,
4 Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, 5 Neuralstem Inc, Rockville,
Maryland, United States of America, 6 Department of Neurology, University of Michigan, Ann Arbor, Michigan, United States of America, 7 Ludwig Institute and
Department of Cellular and Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, California, United States of America, 8 Institute of Animal
Physiology and Genetics, Academy of Sciences of the Czech Republic, Libechov, Czech Republic, 9 Department of Cell Biology, Faculty of Science, Charles University in
Prague, Prague, Czech Republic
Abstract
Background: Mutation in the ubiquitously ex
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