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Human Molecular Genetics, 2004, Vol. 13, No. 5 509–524
DOI: 10.1093/hmg/ddh051
Advance Access published on January 6, 2004
Human tra2-beta1 autoregulates its protein
concentration by influencing alternative
splicing of its pre-mRNA
1,{ 1 2 1,*
Peter Stoilov , Rosette Daoud , Oliver Nayler and Stefan Stamm
1Institute of Biochemistry, University of Erlangen, Fahrstraße 17, 91054 Erlangen, Germany and
2Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland
Received October 15, 2003; Revised December 11, 2003; Accepted December 22, 2003
HTRA2-BETA1 is an SR-like protein that regulates alternative splice site selection in a concentration-dependent
D
manner. Its proper concentration is important as several pathological states are associated with its change. We o
w
n
investigated the mechanism that controls the cellular HTRA2-BETA1 concentration and found it utilizes a l
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