Increased breast cancer risk at high plasma folate.pdfVIP

Increased breast cancer risk at high plasma folate.pdf

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Increased breast cancer risk at high plasma folate concentrations among women with the MTHFR 677T allele1–3 ˚ Ulrika C Ericson, Malin IL Ivarsson, Emily Sonestedt, Bo Gullberg, Joyce Carlson, Hakan Olsson, and Elisabet Wirfalt ¨ ABSTRACT THF leads to the other crucial form: 5-methyl THF. This form Background: Folate is involved in DNA synthesis and methylation may have a critical role in carcinogenesis, because it transmits and may thereby influence carcinogenesis. methyl groups for reactions that lead to DNA methylation (2). Objectives: We examined plasma folate (P-folate) concentration in The consequences of altered availability of methyl units for relation to genotypes of the folate-metabolizing enzyme methyl- DNA methylation are complex (3). enetetrahydrofolate reductase [MTHFR 677C /T (rs1801133) and Global genomic hypomethylation may lead to cancer de- 1298A /C (rs1801131)]. We also explored whether P-folate was velopment because it causes chromosomal instability (3). Methyl D associated with risk of postmenopausal breast cancer overall and in deficiency, however, through induced activity of DNA methyl- o

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