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University of Wollongong Research Online Faculty of Science, Medicine and Health - Papers Faculty of Science, Medicine and Health 2009 Inc eases in peptide Y-Y levels following oat β- glucan ingestion a e dose-dependent in ove weight adults Eleanor J. Beck University of Wollongo ng, eleanor@.au Linda C. Tapsell University of Wollongo ng, ltapsell@.au Ma ijk a J. Batte ham University of Wollongo ng, marijka@.au Susan M. Tosh Ag riculture and Ag ri-Food Canada, susan.tosh@agr.gc.ca Xu-Feng Huang University of Wollongo ng, xhuang@.au Publication Details Beck, E. J., Tapsell, L. C., Batterham, M. J., Tosh, S. M. Huang, X . (2009). Increases in peptide Y-Y levels following oat β-glucan ingestion are dose-dependent in overweight adults. utrition Research, 29 (10), 705-709. Research Online is the open access institutional repository for the University of Wollongong. For further information contact the UOW Library: research-pubs@.au Inc eases in peptide Y-Y levels following oat β-glucan ingestion a e dose- dependent in ove weight adults Abstract Peptide Y-Y (PYY) is an anorexigenic hormone implicated in appetite control, and β-glucan is a fiber known to affect appetite. We hypothesized that plasma PYY levels would increase in overweight human adults consuming increasing doses of β-glucan. The objective was to test whether the effect could be seen with β- glucan delivered through extruded cereals containing a high β-glucan oat bran with demonstrated high molecular weight and solubility. Fourteen subjects consumed a control meal and 3 cereals of varying β-glucan concentration (between 2.2 and 5.5 g), and blood samples were collected over 4 hours. Analysis of raw PYY data showed a trend toward