- 1、本文档共16页,可阅读全部内容。
- 2、有哪些信誉好的足球投注网站(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
LETTER
doi:10.1038/nature13564
Interleukin-22 alleviates metabolic disorders and
restores mucosal immunity in diabetes
1 1 1 2 2 1 1
Xiaoting Wang *, Naruhisa Ota *, Paolo Manzanillo , Lance Kates , Jose Zavala-Solorio , Celine Eidenschenk , Juan Zhang ,
1 1 2 3 2 2 1
Justin Lesch , Wyne P. Lee , Jed Ross , Lauri Diehl , Nicholas van Bruggen , Ganesh Kolumam * Wenjun Ouyang
The connection between an altered gut microbiota and metabolic mice, and in diet-induced obese (DIO) C57BL/6 mice fed with high-fat
disorders such as obesity, diabetes, and cardiovascular disease is diet (HFD) (Extended Data Fig. 1a–i). Leptin itself did not directly en-
well established1,2. Defects in preserving the integrity of the muco- hance IL-22 production from either ILCs or T cells in vitro (data not
sal barriers can result in systemic endotoxaemia that contributes to shown). Previous studies demonstrated that immune responses such
chronic low-grade inflammation, which further promotes the devel- as the generation of TH subsets under specific immune challenges were
opment of metabolic syndrome3–5. Interleukin (IL)-22 exerts essential compromised in leptin-deficient mice14–17. However, under our exper-
roles in eliciting antimicrobial immunity and maintaining mucosal imental conditions, only IL-171 TH 17 cells besides IL-221 T cells,
barrier integrity within the intestine6,7. Here we investigate the con- but not other TH
您可能关注的文档
- Intangible capital in the pharmaceutical & chemical industry;.pdf
- INTEGERS ELECTRONIC JOURNAL OF COMBINATORIAL NUMBER THEORY.pdf
- INTEGRABILITY OF A NON-AUTONOMOUS COUPLED KdV SYSTEM - Middle.pdf
- Integrated assessment of global water strongscarcitystrong over the 21st.pdf
- Integrated LFSR Reseeding, Test-Access Optimization, and Test.pdf
- Integrating a Simulated strongUAVstrong in a Live Exercise - TNO.pdf
- Integrating Advanced GLSL Shading and XML Agents into a.pdf
- INTEGRATING ELECTRIC VEHICLES INTO SMART GRID INFRASTRUCTURES.pdf
- Integrating exhibit marketing into integrated marketing.pdf
- Integrating Grey and Green strongInfrastructurestrong to Improve the.pdf
文档评论(0)