Michigan molecular interactions r2 from interacting proteins.pdfVIP

D642–D646 Nucleic Acids Research, 2009, Vol. 37, Database issue Published online 31 October 2008 doi:10.1093/nar/gkn722 Michigan molecular interactions r2: from interacting proteins to pathways V. Glenn Tarcea, Terry Weymouth, Alex Ade, Aaron Bookvich, Jing Gao, Vasudeva Mahavisno, Zach Wright, Adriane Chapman, Magesh Jayapandian, ¨ Arzucan Ozgu¨ r, Yuanyuan Tian, Jim Cavalcoli, Barbara Mirel, Jignesh Patel, Dragomir Radev, Brian Athey, David States and H. V. Jagadish* Center for Computational Medicine and Biology, University of Michigan, Ann Arbor, MI 48109, USA Received September 16, 2008; Accepted September 30, 2008 ABSTRACT sharing of interaction information across multiple data- bases maintained by independent curators. However, all Molecular interaction data exists in a number of of these databases perform ‘shallow integration’: they repositories, each with its own data format, mole- make access convenient for the user by making all data cule identifier and information coverage. Michigan available at one place, but make no attempt to pull that molecular interactions (MiMI) assists scientists data into a cohesive whole. Source databases have over- searching through this profusion of molecular lapping coverage, resulting in multiple entries of the same interaction data. The original release of MiMI gath- information in the integrated result. For example, the ered data from well-known protein interaction data- same source public