急性ST段抬高型心肌梗死患者外周血Apelin水平变化意义.pdfVIP

临床研究 急急性性STST 段抬高型心肌梗死患者外周血段抬高型心肌梗死患者外周血ApelinApelin 水平变化的意义水平变化的意义 及其及其预后价值预后价值 1 2 1 1 1 1 申 健 ，张 旭 ，李志明 ，谢桂庭 ，农盛雄 ，申源生 1 2 广东省惠州市中心人民医院 心血管内科，药剂科，广东 惠州 516001 摘要：目的本研究的主要目的是探讨急性ST段抬高型心肌梗死患者apelin水平变化的意义与一年预后的关系。方法 测定93 位接受直接PCI 的STEMI 患者、30 位接受择期PCI 的STEMI 患者、30 位接受择期PCI 的稳定型心绞痛患者及10位健康志愿者 不同时段外周血apelin水平，同时收集相应的临床资料。行冠脉造影术后予以Gensini评分。在患者入院时及随访一年（或终点 事件）时评估左室射血分数（LVEF）。结果 STEMI 患者外周血apelin 水平降低，直接PCI 后apelin 水平上升，差异有统计学意 义；择期PCI 的STEMI患者PCI 术后apelin水平无显著变化，且低于接受直接PCI 的患者；apelin水平与糖化血红蛋白负相关；一 年随访表明，apelin水平降低与低LVEF 相关，但难以预测一年终点事件。结论 外周血apelin 可能为急性ST段抬高型心肌梗死 即时及预后的参考指标。 关键词：急性心肌梗死；apelin ；NT-proBNP ；预后 Peripheral blood apelin level in patients with acute ST-elevation myocardial infarction and its prognostic value 1 2 1 1 1 1 SHEN Jian , ZHANG Xu , LI Zhiming , XIE Guiting , NONG Shengxiong , SHEN Yuansheng 1Department of Cardiovascular Diseases, 2Department of Pharmacy, Huizhou Municipal Central Hospital, Huizhou 516001, China Abstract: Objective To investigate peripheral blood apelin levels in patients with acute ST-elevation myocardial infarction (STEMI) and their correlation with the one-year outcome of the patients. Methods A total of 153 consecutive patients, including 93 with acute STEMI undergoing primary percutaneous coronary intervention (PCI), 30 with acute STEMI and 30 with stable angina all undergoing elective PCI, and 10 healthy control subjects were examined for peripheral blood apelin levels and clinical parameters. The composite endpoints (CEPs) were determined at the one year follow-up. Results Apelin levels were significantly decreased in all the patients at admission, but increased following primary PCI. Apelin levels showed a negative