黄连生物碱的提取分离.ppt

* 黄连生物碱提取与分离 * 黄连生物碱提取与分离 一、Introduction(药品介绍) 【药??材??名】黄连 【英??文??名】Golden Thread 【拉??丁??名】Rhizoma Coptidis 【科目来源】双子叶植物药毛茛科植物 【药用部位】黄连,三角叶黄连,峨嵋野地连或云南黄连的根茎。 * 二、Pharmacological activity（药理活性） Coptis chinensis Franch, of the Ranunculaceae family,is a perennial, stemless herb that grows throughout China.Coptidis Rhizoma, the rhizome of C. chinensis, has commonly been prescribed for treatment of diabetes mellitus in Chinese traditional herbal medicine for a long time due to its blood sugar-lowing properties. It also relaxes blood vessels, lowers fevers, stimulates circulation, and exerts anti-bacterial, antiviral, and antifungal activity.In addition, Coptis chinensis are reported to possess antiinflam-matory, anti-proliferative, antioxidant, and antihypertensive activities, as well as hypoglycemic and hypochole-sterolemic effects. * Coptidis Rhizoma is known to harbor a diversity of alkaloids, including berberine, palmatine, jateorr-hizine, piberberine, and coptisine, which are consi-dered to be its active constituents. In particular, berberine the most predominant component and shows various pharmacological and biological effects, including anti-hypertensive, anti-diabetic, antiinflam-matory, hypolipidemic,and antioxidant effects. Berberine, palmatine, and jateorrhizine have been reported to exhibit hypoglycemic and hypocholes-terolemic effects. reported that coptisine, palmatine, magnoflorine, and epiberberine might contributeo the protective effects of Cotidis Rhizoma on oxidati-veress, Jateorrhizine and magnoflorine were also reported to exhibit significant anti-oxidant and anti-radical capacities. * 三 黄莲生物碱提取工艺流程图 * * * REFERENCES 1、Inhibitory Activities of the Alkaloids from Coptidis Rhizoma against Aldose ReductaseArch. Pharm Res Vol 31, No 11, 1405-1412, 2008 2、A New and Weakly Antispasmodic Protoberberine Alkaloid from Rhizoma Coptidis.Phytother. Res. 24: 1414–1416 (2010) *