钆特酸葡胺摘要.ppt

钆特酸葡胺适用于全身各部增强应用 The low incidence of adverse reactions (1%) and the absence of serious adverse reactions reported during the survey period showed that Gd-DOTA was very well tolerated. In conclusion, the use of Gd-DOTA as an MRI-enhancing contrast medium in the clinical practice setting appears to be safe and effective. 观察共3444例患者，包括儿童(1个月~14岁) 41例使用钆特酸葡胺的MR增强的安全性和有效性。 钆特酸葡胺安全性高，也适用于婴幼儿 Gadoteric acid is a well-tolerated MRI contrast medium in patients with and without risk factors that is associated with a low rate of adverse events and good or excellent image quality in most patients 观察共84000例患者，不良反应事件发生率(0.34%)，仅8例发生重度不良反应，的MR增强的安全性和有效性。 钆特酸葡胺安全性高，也适用于婴幼儿 Eur J Radiol. 2012 May;81(5):885-90. doi: 10.1016/j.ejrad.2011.04.022. Epub 2011 May 8. Tolerability and diagnostic value of gadoteric acid in the general population and in patients with risk factors: results in more than 84,000 patients. Maurer M1, Heine O, Wolf M, Durmus T, Wagner M, Hamm B. 大环状结构牢固地“笼”住钆原子 钆喷酸葡胺 (Gd-DTPA) N N Gd 3+ N - 2 CO - 2 CO - 2 CO - O C 2 - O C 2 - 线性结构 欧乃影 (Gd-DTPA-BMA) N N N CO N CH 3 H N H Gd 3+ 2 CO - 2 CO - O C O C 2 - CH 3 - ? 钆特酸葡胺 Gd-DOTA Gd 3 + N N N N O C 2 - 2 CO - 2 CO - 2 CO - 环形结构 钆特酸葡胺为唯一的离子环形含钆螯合剂，稳定性最佳 钆特酸葡胺在稳定性及安全性方面全面优于同类MRI造影剂 钆特酸葡胺至今未出现NSF不良反应报道，属于NSF低风险类对比剂 总结 1 2 3 * ) * Slides 12 and 13. Paramagnetic contrast agents currently on the market can be classified as ionic or non-ionic and as linear or macrocyclic structures. Magnevist? e Dotarem? are ionic compounds. Their solution needs to be salified (i.e. with meglumine) in order to neutralize the positive charge of gadolinium. ProHance? e Omniscan? are non-ionic compounds, and therefore they do not need to be salified. Their solutions have therefore lower osmolality (630 e 796 mOsm/kg, respectively) compared to those of the ionic agents Dotarem? e Magnevist? (1.340 e 1.940 mOsm/kg, respectively). Although differences in osmolality are significant, contrast agents for MRI are usually a