缺铁性贫血巨幼细胞贫血要点.ppt

L/O/G/O Iron Deficiency Anemia Megaloblastic Anemia Iron Deficiency Anemia What is Iron Deficiency Anemia? Iron deficiency anemia (IDA) is a common anemia?(low red blood cell level) caused by insufficient dietary intake and absorption of iron, and/or iron loss from intestinal bleeding. Iron deficiency causes approximately half of all anemia cases worldwide, and affects women more often than men.? Iron Deficiency Anemia Iron depletion Iron deficient erythropoiesis Iron deficiency anemia Iron deficiency can be divided into three phases The first phase The second phase The third phase Cause I D A Blood Loss A lack of iron in the diet An inability to absorb iron Preg- nancy Pathogenesis The influence on iron metabolism The influence on hematopoietic system The influence on the metabolism of tissue cells Hemogram Human blood from a case of iron deficiency anemia Peripheral blood film of a patient with iron deficiency anemia Hemogram ?Blood smear of a patient with?iron deficiency anemia?at 40x enhancement Megaloblastic Anemia What is Megaloblastic Anemia? Megaloblastic anemia is an anemia (of macrocytic?classification) that results from inhibition of?DNA synthesis?in red blood cell production. The obstruction of DNA synthesis leads to continuing cell growth without division, which presents as macrocytosis. .? Cause ?vitamin B12 deficiency folic acid deficiency others The inhibition of? DNA synthesis MgA Cause Pathogenesis The defect in red cell DNA synthesis is most often due to hypovitaminosis, specifically a deficiency of?vitamin B12 and/or?folic acid. ?When DNA synthesis is impaired, the?cell cycle cannot progress from the G2 growth stage to the mitosis (M) stage.? The pathological state of megaloblastosis is characterized by many large immature and dysfunctional red blood cells (megaloblasts) in the bone marrow and also by?hypersegmented neutrophils. Hematological findings Decreased?red blood cell (RBC) cou