第三补体精要.pptx

第三章 补体Complement;内容;Complement: history;; 补体，存在于新鲜血清中，能够裂解抗体包被的细胞。 这种活性可以经加热56℃，30分而灭活 (失活)。;Complement;（一）理化性质及生成部位 1 补体多属β球蛋白，少数属α或γ球蛋白； 2. 各补体成分的分子量及血清含量不一,C3含量最高； 3. 性质很不稳定；一般保存于零下20摄氏度； 4 均对热敏感，56℃ 30分钟可灭活； 5. 主要由肝细胞、巨噬细胞产生 （二）补体系统的组成 1．补体的固有成分 经典途径的C1q、C1r、C1s、C4、C2； MBL途径的MBL（甘露聚糖结合凝集素）和丝氨酸蛋白酶； 旁路途径的B因子、D因子； 三条途径的共同末端通路C3、C5~C9。 2．调节蛋白：备解素（P因子）、C1抑制物、I因子、H因子、C4结合蛋白等。 3．补体受体：CR1~CR5、C3aR、C2aR、C4aR等。;补体的功能;Complement;补体系统的组成;补体系统的特点;Complement lack;The Complement System;Part 2;Proteins of the complement system;补体的存在形式及其命名方法;17;Part 3;Complement System: Overview;Pathways of complement activation;Activation of the Complement System;Complement activation;Activation of the Complement System;Activation process of the Classical Pathway;C1q;26;;;29;活化阶段;;C5转化酶的形成;攻膜阶段;;;36;The Complement System kills microbes via the Membrane Attack Complex (MAC)膜攻击复合物;;Components of the Classical Pathway;;;;;;Activation of the Classical Pathway;Activation process of the Alternative Pathway;补体活化的旁路途径;Activation of the Alternative Pathway;;;;;;;Components of the alternative pathway;Spontaneous C3 activation;B;C3a;C3a;C3a;C3a;Control of spontaneous C3 activation via DAF;;Autologous cell membrane;;C3b stabilization and C5 activation;C3b regulation on self and activator surfaces;Activation process of the MBL Pathway; 由MBL结合病原体甘露 糖残基引起的补体系统 激活过程 阶段： 识别阶段 活化阶段 攻膜阶段;MBL的立体结构 （类似C1q）;;Activation of the Lectin Pathway;Components of mannose-binding lectin pathway;Mannose-binding lectin pathway;;不同途径补体系统激活的比较;77;C5-convertase of the two pathways;Generation of C5 convertase leads to the activation of the Lytic pathway;Components of the lytic pathway;Lytic pathway C5-activation;;;;Biological properties of C-activation products;Biological properties of C-activation products;Biological properties of C-activation products;Effector Actions of Complement;Part 4 Complement functions;Complement functions;;;Complement prote