降低急救中心泛耐药鲍曼不动杆菌数-globalsummit.ppt

Contents Introduction Objective Methods Results Conclusion Introduction Cervical cancer is the fourth most common malignancy in women in the world and it remains a?leading?cause?of?cancer-related death of women. HPV is considered as the primary risk factor in the development of cervical cancer. However, only HPV infection may not induce cervical cancer, many cofactors of cervical cancer have been established for female with persistent infection. Introduction Folate receptor alpha (FRα), called as folate binding protein (FBP), is a membrane-bound protein linked to cell surfaces via a glycosylphosphatydilinositol (GPI) anchor. FRα has a high affinity to mediate folate uptake by endocytosis. FRαis highly expressed in human cancer tissues and cells, but lower in normal tissues. FRαis highly expressed in human cervical cancer Hela cells. Introduction ERK signaling pathway has been reported in many human carcinomas, but the association between ERK signaling pathway and cervical cancer is inconclusive. ERK1 and ERK2 proteins are the important factors in ERK signaling pathway and associate with many cancers. ERk1/2 is highly expressed in human cervical cancer. Introduction It is reported that both FR-targeted liposomes loaded with carboplatin or empty FR-targeted liposomes exhibited the significantly increase ERK phosphorylation (Chaudhury A et al, 2012). Introduction Src?protein is one of the members of Src family kinase. Src ?protein could be activated by cell membrane receptors, such as growth factor receptor and integrin receptor and G protein coupled receptor. Introduction Phosphorylated Src protein could further activate the ERK signaling pathway. When phosphorylated ERK1/2 enter the nucleus, many transcription factors could be phosphorylated, such as c-Fos, c-Jun, c-myc, cyclin-D1 and Bcl-2. Introduction The c-Fos and c-Jun are the major nuclear transcription proteins and they usually play a key role in cell proliferation and apoptosis. It is repor