依达拉奉联合许旺细胞移植能够修复脊髓损伤.docVIP

依达拉奉联合许旺细胞移植能够修复脊髓损伤？ 依达拉奉是自由基清除剂，具有抑制血管内皮细胞损害，延缓神经细胞凋亡，改善神经功能和减轻神经缺血的作用，可能改善脊髓损伤区微环境，为许旺细胞移植治疗脊髓损伤提供有利环境。来自中国天津市南开医院张树泉 辣根过氧化物酶逆行神经示踪，依达拉奉联合许旺细胞移植治疗T9脊髓全横断损伤模型大鼠，在损伤脊髓中可见到较多辣根过氧化物酶阳性颗粒标记的神经纤维 Article: Edaravone combined with Schwann cell transplantation may repair spinal cord injury in rats, by Shu-quan Zhang1, Min-fei Wu2, Zhe Piao1, Jin Yao1, Ji-hai Li1, Xin-gang Wang3, Jun Liu4 (1 Department of Orthopedics, Tianjin Nankai Hospital, Nankai, Tianjin, China; 2 Department of Spine Surgery, Orthopedic Hospital, Second Hospital, Clinical Hospital, Jilin University, Changchun, Jilin Province, China; 3 Department of Burns and Plastic Surgery, China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, China; 4 Department of Hand and Foot Surgery and Reparative Reconstructive Surgery Center, Orthopedic Hospital, Second Hospital, Clinical Hospital, Jilin University, Changchun, Jilin Province, China) Zhang SQ, Wu MF, Piao Z, Yao J, Li JH, Wang XG, Liu J (2015) Edaravone combined with Schwann cell transplantation may repair spinal cord injury in rats. Neural Regen Res 10(2):230-236. 欲获更多资讯： Neural Regen Res May edaravone combined with Schwann cell transplantation repair spinal cord injury？ Edaravone is a free radical scavenger that suppresses vascular endothelial cell damage, delays neuronal apoptosis, improves neurological function and lessens nerve ischemia. Edaravone can provide a favorable environment for the treatment of spinal cord injury using Schwann cell transplantation. Shu-quan Zhang, Tianjin Nankai Hospital, China and his colleagues established rat models of complete spinal cord transection at T9. Six hours later, Schwann cells were transplanted in the head and tail ends of the injury site. Simultaneously, edaravone was injected through the caudal vein. Eight weeks later, the PKH-26-labeled Schwann cells had survived and migrated to the center of the spinal cord injury region in rats after combined treatment with edaravone and Schwann cells. More