Drug elimination metabolism excretion.pptVIP

 Drug elimination (metabolism, excretion) Anton Kohút DRUG METABOLISM major site of drug metabolism – liver,  exceptions:- suxamethonium and procaine  - plasma cholinesterase- tyramine - intestinal wall  Phase 1 - lipophilic molecules are converted into more polar molecules Reactions are catalyzed by the cytochrome P-450 (CYP) by: ? oxidation ? reduction ? hydrolysis - products are often less eactive than the parent compounds - after metabolism may be excreted by kidneys - each of the enzym