丝裂霉素C不影响周围神经结构与功能的最佳浓度.docVIP

丝裂霉素C不影响周围神经结构与功能的最佳浓度 近年来，在脊柱外科领域，椎板切除术后局部瘢痕粘连的问题一直困扰着国内外学者。人们尝试使用一种经典的抗肿瘤药物丝裂霉素C来有效抑制椎板切除后瘢痕粘连，并取得了一定的进展。然而以往有报道称，丝裂霉素C局部应用时可对听神经及视神经产生毒副作用，至于其是否会影响周围神经的结构和功能，科学家们仍然不是十分清楚。中国南京医科大学第一附属医院眭涛博士及其同事证明，即使在丝裂霉素C局部使用浓度高达0.7 mg/mL时，未见对周围神经功能产生明显影响；且在浓度不超过0.5 mg/mL时，对周围神经的结构亦未见明显影响，但实验发现0.7mg/mL的丝裂霉素C可显著减少周围神经的髓鞘厚度。该结果表明，周围神经损伤区局部低浓度丝裂霉素C治疗椎板切除后瘢痕粘连是安全的，但高浓度丝裂霉素C（大于0.7 mg/mL）对周围神经功能存在潜在危险。相关文献发表于《中国神经再生研究（英文版）》杂志2014年4月第8期。 苏木精-伊红染色显示大鼠坐骨神经损伤区局部使用0.7mg/mL的丝裂霉素C可显著减少坐骨神经的髓鞘厚度 Article: Potential risk of mitomycin C at high concentrations on peripheral nerve structure, by Tao Sui1, Jinhong Zhang2, Shihao Du1, Changhui Su3, Jun Que4, Xiaojian Cao1 (1 Department of Orthopedics, the First Affliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China; 2 Department of Orthopedics, the Second Hospital of Nanjing, Affliated to Southeast University, Nanjing, Jiangsu Province, China; 3 Department of Orthopedics, Affliated Hospital of Taishan Medical College, Taishan, Shandong Province, China; 4 Department of Intensive Care Unit, the First Affliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China) Sui T, Zhang JH, Du SH, Su CH, Que J, Cao XJ. Potential risk of mitomycin C at high concentrations on peripheral nerve structure. Neural Regen Res. 2014;9(8):821-827. 欲获更多资讯Neural Regen Res The optimal mitomycin C concentration for intact peripheral nerve structure and function Recently, local scar adhesion after laminectomy always challenges the worldwide scholars engaged in spine surgery. Mitomycin C, a classical anti-tumor drug, has been attempted to be used to effectively inhibit scar adhesion after laminectomy and some encouraging outcomes have been achieved. However, there is evidence that mitomycin C has inherent toxicity and other side effects when it is locally used. Whether mitomycin C can influence peripheral nerve structure and function remains unclear. Dr. Tao Sui and his team, the First Affiliated Hospital of Nanjing Medical Univer