结合磁共振弥散加权成像(DWI)及波谱成像(MRS)评价急性脑梗死药物治疗疗效的临床介绍.doc

结合磁共振弥散加权成像（DWI）及波谱成像（MRS)评价急性脑梗死药物治疗疗效的临床研究 韩立秀 张振华 张鹏 张子宪 胡屹伟 【摘要】目的:结合磁共振弥散加权成像(Diffusion weighted MRI ，DWI）及氢质子波谱成像(H magnetic resonance spectroscopy，MRS)NIHSS评分较治疗前均有所降低，治疗组较对照组下降明显(P0.05)，两组病人NAA／Cr(P0.05)。两组病人CHO/Cr及(P0.05)，以上结果分析差异均有统计学意义。结论：应用MRS结合DWI能更好的指导临床治疗，脑蛋白水解物（施普善）是一种有效的治疗急性脑梗死的神经保护剂。 【关键词】： 急性脑梗死 磁共振氢质子波谱 磁共振弥散加权成像 cerebrolysin(施普善） Combined with diffusion-weighted MRI （DWI ）and magnetic resonance spectroscopy (MRS) evaluate clinical effects ?in the Different Treatment of the acute cerebral infarction . 通讯作者：韩立秀，277100，山东枣庄市立医院干部保健科，邮箱：hanlixiu001@163.com [Abstract] Objective: To observe clinical effects ?on the Different Treatment of the acute cerebral infarction Combined with diffusion-weighted MRI （DWI ）and magnetic resonance spectroscopy (MRS). Method: 40 patients who had onset of acute cerebral infarction within 24 hours were randomly divided into treatment group (n=20) or the control group (n=20).National institute of health stroke scale(NIHSS) and application in interest on MRS area measurement N-acetylaspartate (NAA) and creatine (Cr) ratio (NAA/Cr); Choline complex (Cho) and creatine (Cr) ratio (Cho/Cr) and lactic acid (Lac) and creatine (Cr) ratio (Lac/Cr)were compared beteen two groups. Results: There were significant differences in NIHSS between treatment group and the control group after 2 weeks.The improvement in cerebrolysin treatment group was more significant than that of the control group(P 0.05). NAA/Cr were higher in cerebrolysin treatment group than that of the control group ,the differences were significant (P 0.05). Two groups of patients CHO/Cr and Lac/Cr were lower in cerebrolysin treatment group than that of the control group ,the differences were significant (P 0.05). Conclusion: Clinical application of MRS combining DWI can better guide the treatment, cerebrolysin is an effective neuroprotective agent in treating acute cerebral infarction . Key words: the acute cerebral infarction ; infarctio