前列腺癌争议话题讨论教材.ppt

Multivariable Regression Results Presented By Dawn Hershman at 2015 ASCO Annual Meeting ADT治疗的早期是CVD发生的危险时期 Summary Presented By Dawn Hershman at 2015 ASCO Annual Meeting 谢 谢 * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * In conclusion, IAD is currently widely offered to patients with PCa in various clinical settings, and its status should no longer be regarded as investigational (LE: 2). 存在什么问题？ 是否回加速疾病进展？ PSA是否是合适的判断指标？ 缺乏大样本的随机对照研究 间歇性内分泌治疗临床研究 Overall, eight randomised trials are underway, only some of which have published findings. Most of the trials included a mixed patient population, i.e. both locally advanced and metastatic disease. Only three trials included only metastatic patients, and two trials only relapsing patients. The two largest trials each contained more than 1,300 patients, with one trial focused only on metastatic patients (SWOG 9346) and the other on relapsing patients after radiotherapy (SWOG JPR7) 间歇雄激素去除与持续雄激素去除治疗激素敏感性转移性前列腺癌: 国际III期临床研究SWOG 9346 (INT-0162)结果 Hussain M, Tangen CM, Higano CS, Crawford ED, Liu G, Wilding G, Prescott S, Akdas A, Small EJ, Dawson NA, Donnelly BJ, Venner P, Vaishampayan UN, Schellhammer PF, Quinn DI, Raghavan D, Vogelzang NJ, Thompson Jr, IM Univ. of Michigan, Ann Arbor, MI; SWOG Statistical Center, Seattle, WA; Fred Hutchinson Cancer Research Center, Seattle, WA; University of Colorado Health Science Center, Aurora, CO; University of Wisconsin Carbone Cancer Center, Madison, WI; St. James University Hopsital, Leeds, UK; Marmara University, Istanbul, Turkey; University of California, San Francisco, San Francisco, CA; Georgetown University Hospital Lombardi Comprehensive Cancer Center, Washington, DC; Prostate Cancer Institute, Calgary, Alberta, Canada, Calgary, AB; Cross Cancer Institute, Edmonton, AB; Karmanos Cancer Institute, Wayne State University, Detroit, MI; Urology of Virginia, Norfolk, VA; University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA;