24-硕士研究生课-现代分子生物学-专题-细胞凋亡与肿瘤治疗-刘小珊.ppt

ApoptosisNov, 2008 Cell sociology Cell death Zakeri Z, Lockshin RA. Cell death: history and future. Adv Exp Med Biol. 2008;615:1-11. Zakeri Z, Lockshin RA. Cell death in health and disease. Journal of cellular and molecular medicine, 2007;11: 1214-1224. Richard A. LockshinFrom Wikipedia, the free encyclopedia In 1964, Lockshin and Williams published their landmark contribution on Endocrine potentiation of the breakdown of the intersegmental muscles of silkmoths, in which they coined the term, programmed cell death“ Richard Lockshin has made significant contributions to the cell death community. He was one of the founders of the International Cell Death Society and acted as the societys President from 1998 to 2002. Richard Lockshin is currently a professor at St. Johns University (Jamaica, NY). Programmed cell death Cell death Dying cell (in the process of cell death)  Dead cell Enzymological Classification of Cell Death Programmed cell death Programmed cell death=apoptosis=caspase activation= non-immunogenic cell death Cancer and cell death Programmed cell death Application of Cell death in cancer Preventive medicine Carcinogenesis, Prevention of cancer Clinical medicine Diagnosis Therapy Prognosis * Cell behavior Proliferation Differentiation Cell death Cell mobility Definition of cell death Cell death types Cell death types Cell death types Cell Death Differ. 2007;14(7):1237-43. The above is not correct PubMed 1972年Br J Cancer. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. 1965年 autophagy Pub number Why the research of cell death become popular Techniques Genetics Ubiquity Disease Cancer-cell behavior Unlimited proliferation Blocked differentiation Escaping cell death High mobility Chemotherapy, radiotherapy, surgery, biological therapy The goal of cancer treatment :selectively kill cancer cells Cell death types in cancer cell Necro