加味八珍汤联合催产素促进宫颈成熟的临床研究-中国中药杂志.doc

加味八珍汤联合催产素对足月妊娠孕妇宫颈成熟影响的临床研究 180名，随机分为治疗组即加味八珍汤联合催产素组60名，对照组即催产素组60名，空白对照组即期待观察组60名。观察用药前后各组宫颈成熟度评分（Bishop评分）、阴道和宫颈分泌物胎儿纤连蛋白（FFN）定性检测结果、分娩结局及对母胎的影响。研究结果表明，治疗组孕妇宫颈评分在用药后明显优于对照组、空白对照组（P＜0.05）。FFN测定在治疗组用药后与对照组、空白对照组间差异有统计学意义( P ＜0.05 ) 。三组孕妇用药后治疗组临产率、阴道分娩率均高于其它两组，差异有统计学意义（P＜0.05）。治疗组剖宫产率明显低于其它两组，差异有统计学意义（P＜0.05）。三组均未出现新生儿窒息的现象。加味八珍汤联合催产素能有效地促宫颈成熟和引产，使用方便，安全可靠，对母儿无明显不良影响，在降低剖宫产率，促进自然分娩上起到积极作用。 关键词 加味八珍汤,催产素,宫颈成熟 Clinical Study of Jiawei Bazhen Decoction Combined with Oxytocin for Cervical Ripening of Qi and Blood Deficiency Type of Pregnant Women KE Xiao-yan,CHEN Bao-yan,XU Hui-fang,LI Dao-cheng,LI Yan-fang,SUN Xue (The First Affiliated Hospital of Guangzhou University of TCM,510405,Guangzhou,China) Abstract To study preliminarily the effect of Jiawei Bazhen decoction combined with oxytocin in promoting cervical ripening of full-term pregnancy women who were in the deficiency of qi and blood type through the syndrome differentiation of TCM. 180 patients that met the inclusion criteria of the study were randomly divided into three groups : the control group(oxytocin group), the treatment group ( Jiawei Bazhen decoction combined with oxytocin group), the blank control group (expected and observation group) . Cervical maturity score (Bishop score), vaginal and cervical secretions fetal fibronectin (FFN), the result of induced labor, the result of mother and baby were observed in each group before and after treatment . The result comes out that the cervical Bishop score of pregnant women for treatment group were significantly higher than the control group and blank control group after treatment (P 0.05). The FFN of pregnant women for the treatment group were significantly different from the control group and blank control group after treatment (P 0.05) . The pregnancy outcome of the three groups: the labor rate and rate of vaginal delivery of the treatment group were higher than the other two groups , and the difference was statistically significant (P 0.05). Th