氨基酸工业菌种设计资料.pptx

氨基酸工业菌种设计;Beijing;Cofounded by CAS and Tianjin Officially approved 2012.11.29 480 persons (800 in 5 years) 3 departments/key labs 4 core facilities 33 PIs New RD model ;Systems and Synthetic Biotechnology Group;Why acids?;More than 50% of world production capacity 60 billion RMB, 25% of Chinese fermentation industry (excluding fuel ethanol, alcohol drinks, beverages);;;Challenge: the IP issue;National needs;Features;Joint efforts;Genomics;Genome-directed patent analysis;Process omics;Design the ideal pathway;Kinetic modeling and in vitro experiments;Fight against feed-back inhibitionstatistical coupling analysis and molecular dynamics based on 3-D structure ;Semi-rational design to relieve allosteric reg. LysC;Transferrable high throughput screening model;Design and construct cell factories for amino acid industry;Summary and outlook;Acknowledgement People from my group Core facility of the institute Funding from COFCO, Fufeng, BCIG,MOST, CAS, CNSF, Tianjin