Relationship between iron and heart disease research.doc

NAME OF ARTICLE IN CHINESE: 铁与心脏病关系研究进展 ________________________________________________________________________ NAME OF ARTICLE IN ENGLISH: Relationship between iron and heart disease research TOPIC OF ARTICLE: Fe has effect on heart disease. WHAT THE ARTICLE IS ABOUT: A new research shows that Fe have effect on heart disease. Relationship between iron and heart disease research Haochun Hua, Zhu Li, Zhong-Ming Qian Key words: Iron; heart disease; free radicals; anemia 1981, Sullivan proposed a new theory to explain male and female coronary heart disease (CHD) morbidity and mortality differences in question. Women because of reduced menstrual blood loss, leaving the iron accumulation, differences in post-menopausal women reduce iron overload. Therefore, he proposed the accumulation of body iron and CHD are directly or indirectly related to the hypothesis - Iron heart disease hypothesis. Until 1992, when Salonen et al reported a direct impact on iron accumulation Finn heart attack, this hypothesis was able to re-emphasis. Animal experiments have found that iron overload would promote the occurrence of atherosclerosis, and food to reduce iron deficiency in rats fed atherosclerotic lesions. Ketone with the iron chelator to effectively remove the iron sand rat model of myocardial iron storage and increased cardiac performance[1]. In fact, many epidemiological investigation has confirmed that, when applied to iron chelator treatment of heart patients, their cardiac function improved[2]. Clinical trials have shown that myocardial ischemic preconditioning can stimulate the synthesis of ferritin, which can absorb too much to participate in redox reactions of iron, it can protect the myocardium. And intravenous iron may increase the symptoms of chronic heart failure(CHF) patients, for patients with anemia CHF more obvious[3]. Iron-induced heart injury mechanisms: (1) iron can promote arterial smooth muscle cells to low-density lipoprotein (LDL) the ro