黄芪苷为何能抑制脑黑质损伤后的铁积聚异常.doc

黄芪苷为何能抑制脑黑质损伤后的铁积聚异常 帕金森病患者脑内黑质部位可出现铁沉积，可能是神经变性疾病神经元死亡的原因之一，脑黑质铁积聚的机制仍不明确。课题组以往研究表明，能降低鱼藤酮致帕金森病大鼠黑质内转铁蛋白二价金属离子转运体1的表达，升高膜铁转运蛋白1的表达能够阻止黑质损伤后铁的积聚，铁以往研究黄芩苷抑制黑质铁积聚 免疫组织化学染色显示，黄芩苷400 μg/mL）负载C6细胞表达Article: Baicalin suppresses iron accumulation after substantia nigra injury: relationship between iron concentration and transferrin expression, by Chunyan Guo, Xin Chen, Pei Xiong Traditional Chinese Medicine School, Capital Medical University, Beijing, China Guo CY, Chen X, Xiong P. Baicalin suppresses iron accumulation after substantia nigra injury: relationship between iron concentration and transferrin expression. Neural Regen Res. 2014;9 6 :630-636 欲获更多资讯：Neural Regen Res Baicalin suppresses iron accumulation after substantia nigra injury A growing number of studies have shown that excessive iron is closely associated with the pathogenesis of Parkinson’s disease. Previous studies from Chunyan Guo and co-workers from Capital Medical University in China have shown that baicalin prevented iron accumulation after substantia nigra injury, reduced divalent metal transporter 1 expression, and increased ferroportin 1 expression in the substantia nigra of rotenone-induced Parkinson’s disease rats. However, the relationship between iron concentration and transferrin expression is still unclear. Based on the previous findings, these scholars further explored the mechanisms of the inhibitory effect of baicalin on iron accumulation observed in Parkinson’s disease rats. Their findings published in the Neural Regeneration Research Vol. 9, No. 6, 2014 indicate that baicalin down-regulated iron concentration, which positively regulated divalent metal transporter 1 expression and negatively regulated ferroportin 1 expression, and decreased iron accumulation in the substantia nigra. Baicalin declined the expression of divalent metal transporter 1 arrow in C6 cells incubated with 400 μg/mL ferric ammonium citrate. Article: Baicalin suppresses iron accumulation after substantia nig