雄激素治疗幻灯片.ppt

Getting old is natural, feeling old can be optional * 这张图大家很熟悉，主要讲的是睾酮的靶器官。睾酮的靶器官其实非常广泛，除了我们接触比较多的是对于男性性生殖器官有促进阴茎的生长、精子的生成以及前列腺生长的功能之外，它还有其它的靶器官，比如对于皮肤，雄性激素特别是睾酮对于毛发生长，脱发，产生皮脂有一定作用。另外对于肝脏来说，可以促进血清蛋白合成。对于骨骼来说，可能会加速线性生长，骨骺端闭合。对于脑部来讲，可以增强性欲，同时能够改善情绪。对于肌肉来说，可以增加力量与容量。对于肾脏来说，可以刺激促红细胞生成素产生。对于骨髓来说，可以刺激干细胞。 * * NOTES As epidemiological data on sexual dysfunction are relatively scant for both women and men, the prevalence and risk of experiencing sexual dysfunction across various social groups was assessed. Therefore, an analysis was performed of data from the National Health and Social Life Survey, a study of sexual behavior in a cohort of US adults (1749 women and 1410 men aged 18 to 59 years). There was a significant 3-fold increased prevalence of “lack of interest in sex” in aging men as compared to young men. Low sexual desire in men was also associated with not being married, daily alcohol consumption, poor to fair health, negative sexual experiences and emotional problems or stress.1 This study confirms findings from a previous study in 220 men in which libido decreased with increasing age.2 Testosterone deficiency dose-dependently decreases libido. However, the threshold level of testosterone under which libido problems start to occur is relatively low (estimated at around 10 nmol/L).3 Reduced libido in aging men is associated with deficiency of bioavailable testosterone2,4, but not of total testosterone.4 References 1. Laumann EO, Paik A, Rosen RC. Sexual dysfunction in the United States. JAMA 1999;281:537-5442. Davidson JM, Chen JJ, Crapo L, Gray GD, Greenleaf WJ, Catania JA. Hormonal changes and sexual function in aging men. J Clin Endocrinol Metab 1983;57:71-773. Buena F, Swerdloff RS, Steiner BS, Lutchmansingh P, Peterson MA, Pandian MR, Galmarini M, Bhasin S. Sexual function does not change when serum testosterone levels are pharmacologically varied within the normal range. Fertil Steril 1993;59:1118-11234. Schiavi RC, Schreiner-Engel P, White D, Mandel