Chapter 31 Herpeviruses 课件.pptVIP

Chapter 24 Outline Classification of herpesviruses Characteristics of herpesviruses Quick diagnosis of herpesviruses Finding inclusion body Detection of viral Ag and specific Ab Detection of viral DNA 1.Serotype :HSV-1 and HSV-2 2.Pathogenicity 2. Infectious mode in B cell Proliferative infection Non-proliferative infection * * HHV 1.Classification P310 Table 24-1 ?α-herpesviruses HHV-1 HSV-1 HHV-2 HSV-2 HHV-3 VZV ? ?-herpesviruses ? ?-herpesviruses HHV-4 EBV HHV-8 HHV-5 CMV HHV-6 HHV-7 ? Shape and structure Glycoprotein spike Linear ds-DNA Cubic nucleocapsid Envelope 120-130nm in diameter 162 capsomeres 2.Characteristics tegument ? Cultivation ---- replicate in intranuclear of human diploid cells and produce cytopathic effect typical CPE: ? intranuclear acidophilic inclusion body ? cell fusion form multinuclear giant cells 核内嗜酸性包涵体 except EBV 细胞融合形成多核巨细胞 ? Pathogenicity ? transmission ? infectious mode of virus on host cells proliferative latent infection infection activate ? common infectious types by many different routes *subclinical infection *primary infection and latent infection *congenital infection *integrative infection 人普遍易感,感染后大多无明显症状 3.Quick diagnosis CMV HSV,CMV,EBV ? by direct contact ? by sexual contact 病人和健康带毒者 HSV-1:主要是直接密切接触, 也有性接触传播 HSV-2:性接触传播为主 ? Source of infection ? Route of transmission ? HSV-infection ? HSV-infection ? Primary infection ? Latent and recurrent infection ? Congenital and newborn infection ? Associated with cancer primary infection anew recurrent infection reactivation of latent virus HSV-1, HSV-2 site of latency 复发性局部疱疹 HSV1---唇癌 HSV2---宫颈癌 大多无明显症状或出现局部疱疹 latent infection HSV-1---三叉神经节 HSV-2---骶神经节 Coldsore or fever blisters 唇疱疹或热性疱疹 ? Single serotype ? Route of transmission ? Primary infection ?Recurrent infection ? varicella chidren ? pneumonia adults --- zoster adults 单侧成簇性水疱群沿神经支配的皮肤排列呈带状，伴有神经痛 孕妇患水痘易致胎儿畸形、流产或死产 通过飞沫和直接接触传播 VZV 1.Species-specif