子宫内膜息肉中雌、孕激素受体基因表达对宫腔镜术后妊娠影.docVIP

子宫内膜息肉中雌、孕激素受体基因表达对宫腔镜术后妊娠影响的研究 周晓景，王芳，牛吉峰 （1. 郑州大学附属洛阳市中心医院生殖医学中心，河南 洛阳471000） 摘要：目的 研究雌激素受体（ER）、孕激素受体（PR）在不孕症子宫内膜息肉（EP）组织中的表达，探讨其与宫腔镜术后妊娠状况的关系。方法 采用逆转录-聚合酶链反应（RT-PCR）检测106例子宫内膜息肉组织中ERmRNA 、PRmRNA表达,以宫腔镜术后3-6个月是否妊娠分为两组：妊娠组与非妊娠组，比较两组间术前子宫内膜息肉组织中ERmRNA 、PRmRNA表达差异，并进行分析。结果 妊娠组ERmRNA的表达低于非妊娠组，但差异无统计学意义（P 0.05）；PRmRNA在妊娠组的表达显著高于在非妊娠组中的表达，差异有统计学意义（P 0.05）；非妊娠组中的复发病例组，其息肉组织中ERmRNA表达显著高于非复发组及妊娠组（P 0.05），而PRmRNA在复发组的表达低于非复发组的表达，差异有统计学意义（P 0.05）。结论PR在EP中的低表达可能是宫腔镜术后仍不孕的因素之一；PR在EP中的低表达及ER的高表达与EP宫腔镜术后复发密切相关。 关键词:子宫内膜息肉；雌激素受体；孕激素受体；宫腔镜；妊娠 Research on the effects of ER、PR gene expression in endometrial polyps to pregnancy after treatment by hysteroscopy Zhou Xiao-jing, Wang Fang, Niu Ji-feng Reproduction Center of Luoyangshi Central Hospital Affiliated Zhengzhou University, Luoyang 471000, China; Abstract: Objective To investigate the expression of estrogen receptor ER and progesterone receptor PR in ectomy of endometrial polyps EP , and to explore their effects to pregnancy after treatment by hysteroscropy. Method 106 cases of EP were obtained from the patients who underwent a surgical trestment by hysteroscopy.ER and PR were examined by semi-quantitative reverse transcription-polymerase chain reaction RT-PCR in 106 cases of EP. Result The mRNA of ER was lower in pregnancy group than that in non-pregnancy group P 0.05 .PR mRNA level were notedly higher in pregnancy group than that in non-pregnancy group P 0.05 .In relapse group of non-pregnancy group , ERmRNA was significantly higher than that in pregnancy group and non-relapse group P 0.05 ,and PRmRNA was significantly lower than that in pregnancy group and non-relapse group P 0.05 .Conclusion Lower PRmRNA level and higher ERmRNA level may be related to pregnancy failing and may be one of the cause for EP relapse after after treatment by hysteroscropy. Key words:Ectomy of endometrial polyps;Estrogen receptor;Progesterone receptor;hysteroscopy;pregnancy 子宫内膜息肉 EP 是一种良性瘤样病变，在青春期后的任何年龄均可发生，可引起月经量增多、经期延长、子宫内膜炎等，在不