肠道菌群与代谢疾病_培训课件.ppt

肠道菌群致癌 INNA SEKIROV, et al., Gut Microbiota in Health and Disease. Physiol Rev 90: 859–904, 2010; 细菌对免疫和干细胞活动 Won-Jae Lee. Bacterial-modulated host immunity and stem cell activation for gut homeostasis. GENES DEVELOPMENT 23:2260–2265 革命带来的机遇 如何应对悄然而来的革命 调节肠道菌群的方法 糖尿病治疗新机遇 Re′my Burcelin, Gut microbiota and diabetes: from pathogenesis to therapeutic perspective. Acta Diabetol (2011) 48:257–273. Rodrigo Bibiloni, et al., 肠道菌群、肥胖和糖尿病. 雀巢年刊 2009;67:35-43. Thank You！！！ 肠道菌群致非酒精性脂肪肝 Valentina Tremaroli Fredrik B?ckhed, Functional interactions between the gut microbiota and host metabolism. NATURE | VOL 489 | 13 SEPTEMBER 2012 肠道菌群导致脂肪肝 Carmine Finelli and Giovanni Tarantino, NONALCOHOLIC FATTY LIVER DISEASE, DIET AND GUT MICROBIOTA. EXCLI Journal 2014;13:461-490 肝脏疾病和SIBO 肠道菌群与代谢性疾病 肠道菌群增加能量储存 Nathalie M. Delzenne Patrice D. Cani, Interaction Between Obesity and the Gut Microbiota: Relevance in Nutrition. Annu. Rev. Nutr. 2011. 31:15–31. 肠道菌群导致能量聚集 Patrice D Cani and Nathalie M Delzenne, Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota. Current Opinion in Pharmacology 2009, 9:737–743. 肠道菌群引发多种代谢疾病 肠道菌群和肥胖 肠道菌群和肥胖是一个新的热门话题 肥胖的定义 肥胖病一般被定义作为有 BMI 30 以上。 体重将近900磅(约400公斤)的里基(Ricky Naputi)现年39岁，是世界最重的男子之一。因为体型过于笨重而难以移动，他已经在坐落于太平洋关岛的家中躺了五年之久。 肥胖和正常人 Amandine Everard Patrice D. Cani, Diabetes, obesity and gut microbiota. Best Practice Research Clinical Gastroenterology 27 (2013) 73–83. 史氏甲烷短杆菌和肥胖 为了确定肠道菌群的改变和验证人体肠道中的乳杆菌或双歧杆菌是否与肥胖或消瘦相关，我们采用定量PCR和乳杆菌选择性培养基分析了68位肥胖志愿者和47位对照的粪便菌群中硬壁菌、拟杆菌、乳酸乳球菌、动物双歧杆菌和若干乳杆菌种的数量。 结果：定量PCR试验中，动物双歧杆菌(OR=0.63; 95% CI 0.39-1.01; P=0.056)和史氏甲烷短杆菌(OR=0.76; 95% CI 0.59-0.97; P=0.03)与正常体重相关，而罗伊氏乳杆菌(OR=1.79; 95% CI 1.03-3.10; P=0.04)与肥胖相关。 Million M, et al., Obesity-associated gut microbiota is enriched in Lactobacillus reuteri and depleted in Bifidobacterium animalis and Methanobrevibacter smithii.Int J Obes (Lond). 2011 Aug 9. 产甲烷肥胖的人有较高的身体质量指数 58人，BMI显着较高的甲烷阳性者（45.2±2.3公斤/米2）比甲烷阴性（38.5±0.8公斤/米2，P= 0.001